NJACS - Mass Spectrometry Group

Upcoming Meeting:

The NJ Mass Spectrometry Discussion Group presents
The April Meeting – Waters Corporation night

“Strategies for Quantitative Analysis of Therapeutic Peptides and Proteins.”

Ignatius Kass, Ph.D.
Sr. Field Marketing Manager, Pharmaceutical Mass Spectrometry, Waters Corp.

II.

“Unraveling Biological Mechanisms with Static and Dynamic Biomarker Analysis”

Dr. Thomas P. Roddy
Director, Analytical Biochemistry in Molecular Biomarkers,Merck & Co., Inc.

• Sponsored by •
Waters Corporation

at the

Holiday Inn, Somerset, NJ

Tuesday, April 17, 2012

5:30 pm	Social and registration
6:15 pm	Complimentary dinner
7:00 pm	Welcome and opening remarks
7:05 pm	Dr. Ignatius Kass, Sr. Field Marketing Manager, Waters Corporation
8:00 pm	Dr. Thomas P. Roddy, Merck & Co., Inc.
8:55 pm	Closing remarks

Speakers & Titles: TBA

“From Discovery to the Routine – Mass Spectrometric Workflows for the Characterization of Protein-Based Biopharmaceuticals”

Kathy Kellersberger, Ph.D.
Senior Product Specialist at Bruker Daltonics

Abstract:

Characterization of a biopharmaceutical compound is essential at each stage during its life-cycle. However, characterization of protein-based biopharmaceuticals is challenging in comparison with their small molecule counterparts due to their high molecular weight and heterogeneous nature. Of the analytical tools available, mass spectrometric methods are some of the most powerful. Here we present an overview of Bruker Daltonics solutions including an automated rapid workflow for the routine characterization of biopharmaceutical products; discovery and development tools for more detailed characterization including primary structure and N-terminal sequence determination, determination of post-translational modifications including glycosylation patterns, and determination of disulphide bonds.

II.

“Plasma Peptide Biomarkers: From Sample to Spectrum”

Jizu Yi, Ph.D.
Principal Scientist / Proteomics R & D at BD Diagnostics

Abstract:

Plasma peptides are found to be rich in a human plasma sample, and contain status information of a variety of diseases. The discovered peptide markers such as FPA, GLP-1, GIP, Glucagon, and Ghrelin, are potentially developed for clinical application. However, these potential metabolic peptide biomarkers like other peptides are subject to preanalytical variability, specifically due to the instability caused by intrinsic proteolysis. The proteolytic instability may result in a barrier in translating discovered biomarkers from research into applications. Using time-course MS analysis, we have characterized the kinetics of digestion of a peptide as a Sequential Multiple-Step Reaction (SMSR). We also developed a time-course MALDI-TOF MS method to evaluate the stability of a potential peptide marker from sample to spectrum. We further developed a technology to minimize this variability and instability using enzymatic inhibitors in the blood collection tube. Stabilization of plasma peptides enables them for further biomarker development from discovery to application.

Attendance is free of charge, compliments of our sponsor!

Please REGISTER HERE

Photos from the April 2012 Meeting

1. Dr. Ron Kong, Chair of NJACS-MSDG, gave the opening remarks.

2. 2012 NJACS-MSDG Student Travel Award winner, Freneil Jariwala (left), with Ron Kong.

3. Dr. Ignatius Kass, Waters Technologies Corporation, presenting at NJACS-MSDG.

4. Dr. Thomas P. Roddy, Merck & Co., Inc., presenting at NJACS-MSDG.

4. Front: Ignatius Kass, Thomas P. Roddy, John Venesky; Back: Jonathan Ho, Brad I. Coopersmith, Robert Iannucci.

Photos from the March 2012 Meeting

1. Ron Kong, Chair of NJACS-MSDG, welcomed attendees

2. Amber Flynn Charlebois, NJACS section chair, gave opening remarks

3. 2012 NJACS-MSDG Distinguished Service Award Winner, Ed Kerns, with Safet Palamar (left) and Ron Kong (right).

4. 2012 NJACS-MSDG Early Career Award Winner, Ileana Cristea, with Safet Palamar (left) and Ron Kong (right)

5. 2012 NJACS-MSDG Achievement Award Winner, Steven Gross, with Safet Palamar (left) and Ron Kong (right)

6. Speakers with the Board of 2012 NJACS-MSD. Front: Safet Palamar, Doug Boyd, Chris Thompson, Darren Hansen; Back: Jonathan Ho, Ron Kong, Robert Iannucci, Fangbiao Li

Photo from the November 2011 Meeting

From left to right, Front: Steven Gross, Jim Lau; Back: Mingxiang Lin,...

Front: Steven Gross, Jim Lau; Back: Mingxiang Lin, Wayne Heacock, Bryan Lavery, Ron Kong

Photo from the MSDG 2011 Annual Fall Vendor Show and Distinguished Lecture – September, 2011

Left: Mingxiang Lin, Right: Distinguished Lecturer Professor David C. Muddiman

Photo from the June 2011 Meeting

Front: Gene Ciccimaro, Jerry Pappas, Qian Ruan Back: Safet Palamar, Mingxiang Lin

Photos from the May 2011 Meeting

1. 2011 NJACS-MSDG Student Travel Award Winner, Rosalynn Molden, Princeton University

2. Front: Hui Wei, Lewis M. Brown, John Venesky, and Safet Palamar Back: Mingxiang Lin, Vin Dell'Ova, Aviva deBeer-heidt, and Robert M Iannucci

Photo from the April 2011 Meeting

Front: Chris Colangelo, Tom Covey and Graham Gibson. Back: Fangbiao Li, Mingxiang Lin and Robert M Iannucci

Photos from the March 2011 Meeting

1. NJACS-MSDG 2011 award lecture recipients with the Board. Front: Benjamin A. Garcia, Mickey O'Brian, Kuangnan Qian. Back: Safet Palamar, Ron Kong, Mingxiang Lin and Robert M Iannucci

2. Early Career Award presented to Benjamin A. Garcia, Ph.D.

3. Achievements in Mass Spectrometry Award presented to Kuangnan Qian, Ph.D.

4. Distinguished Service Award presented to Heather Coales

Photo from the February 2011 Meeting

Speakers with the Board. Front: Kathy Kellersberger, Doug Boyd, Jizu Yi Back: Safet Palamar, Mingxiang Lin, Ron Kong, and Robert M Iannucci

Photos from the December 2010 Meeting

1. MSDG appreciates John's contributions to the community: John Castoro (2010 Chair) and Mingxiang Lin

2. Speakers with the Board. Front: Ragu Ramanathan and Veronica Zelesky. Back: Graham Gibson, Mingxiang Lin and John Castoro

Photos from the NJACS MS Vendor Show - Sept 2010

1. Mixer

2. Prof. R. Graham Cooks receives the 2010 NJ-ACS MSDG Distinguished Lectureship Award Dr. John Castoro, NJACS MSDG Chair (left) and Prof. R. Graham Cooks (right)

Photos from the May 2010 Meeting

1. NJACS-MSDG 2010 student travel award recipients with the Board. Front: Barry Zee, Diana Johnson and Changching Chan. Back: Mingxiang Lin and John Castoro

2. Speakers with the Board. Front: Jose Castro Perez and Brandon Ruotolo. Back: Mingxiang Lin, John Castoro and John Venesky.

Photo from the April 2010 Meeting

Speakers with the Board. Front: Paul West, Jim Lau; Back: Mingxiang Lin, John Castoro, Ron Kong, and Kathleen Anderson

Photo from the March 2010 Meeting

Speakers with the Board. Front: Guodong Chen, Wendy Zhong, Doug Boyd Back: Victor Fursey, Mingxiang Lin, John Castoro

Photo from the Feb 2010 Meeting

Speakers with the Board. Front: Yves LeBlanc, Joseph Dixon Back: Mingxiang Lin, John Castoro, Graham Gibson, Ron Kong

Photos from the Dec 2009 Meeting

1. NJACS-MSDG 2009 award recipients with the Board. Front: Jerry Pappas, Tim Olah, Qian Ruan Back: Mingxiang Lin, John Castoro, Kathleen Cox, Mickey O'Brien

2. Speakers with the Board. Front: Stephen Dueker, Griff Humphries Back: Mickey O'Brien, Mingxiang Lin, Kathleen Cox, John Castoro

Photo from the Nov 2009 Meeting

Front: Professor Robert Cotter, Dr. Ryan Wenzel. Rear: John Castoro, Tom Moran, Kathleen Cox, Scott Kuzdal, Mingxiang Lin

Photos from the May 2009 Meeting

1. ASMS Student award winners with the NJ MSDG Board. Front: Junfeng Xiao, Maria Cecilia Della Valle, Mariana Plazas-Mayorca Back: Mingxiang Lin, John Castoro, Brandy Young, Kathleen Cox, Mickey O'Brien

2. Speakers with the Board. Front: John Venesky, Joanna Barbara, Ignatius Kass Back: Mingxiang Lin, John Castoro, Kathleen Cox, Brandy Young, Mickey O'Brien

Photo from the April 2009 Meeting

Sitting: Russell Grant, Pat Bennett, Liaxin Wang Standing: John Castoro, Kathleen Cox, Brandy Young, Mingxiang Lin

Photo from the March 2009 Meeting

Bottom row: Dr, William Erb, Ethicon; Prof. Jonathan Sweedler, University of Illinois; Top Row: Mingxiang Lin, Secretary; Kathleen Cox, Chair; Doug Boyd, Bruker Daltonics; John Castoro, Treasurer

The MSDG Annual Fall Vendor Show and Distinguished Lecture

was held on Monday, Sept 21, 2009

with 2009 Distinguished Lecturer

Prof. Simon Gaskell

Director of the Michael Barber Centre for Mass Spectrometry and Vice President (Research)

The University of Manchester

speaking on

“Mass spectrometric and ion mobility studies of the gas-phase ion chemistry of peptides”

at The Hilton at East Brunswick in East Brunswick, NJ

Photos from the 2009 Fall Vendor Show

1. Front: Kathleen Cox, Professor Simon Gaskell, John Castoro. Rear: Mingxiang Lin, Mickey O'Brien, Kathleen Anderson

2. Professor Simon Gaskell presenting at the 2009 NJ MSDG vendor show

Mass Spectrometry Awards

NJACS-MSDG sponsors five awards for the promotion of
mass spectrometry in the greater New Jersey region.
(including New York/Connecticut/ Pennsylvania/Delaware).

[ Table of Past Awards ]

New Jersey Regional Award for Achievements in Mass Spectrometry

[ Eligibility/Nomination Form ]

New Jersey Early Career Award in Mass Spectrometry

[ Eligibility/Nomination Form ]

New Jersey Distinguished Service Award in Mass Spectrometry

[ Eligibility/Nomination Form ]

NJACS-MSDG Student Travel Award

[ Eligibility/Nomination Form ]

NJACS-MSDG Distinguished Lectureship

Please Note:

Nominations for NJACS MSDG awards are open for 2012. Please see the eligibility forms for further information.

Student ASMS Travel Award application is due March 15, 2012. Early Career Award, Distinguished Service Award, and Regional Achievement Award applications are due by (TBA).